As the 2000s dawned, Chriqui began appearing in the big screen, with roles in comedies, dramas, and more horror films such as "100 Women" (2000), "Wrong Turn" (2002), and "You Don't Mess With the Zohan" (2008).
With the arrival of the 2010s, Chriqui's career shifted back to television, with leading roles in "Cleaners" (2013-2014) and "The Passage" (2019); and supporting or recurring roles in several other series, such as "The Mentalist" (during the 2012 and 2013 seasons) and Shut Eye (during the first season). Her most recent television role was as Lana Lang on "Superman and Lois", the first 16-episode season aired during 2021. In 2022, she will be seen in a starring role in "Cosmic Dawn", a sci-fi thriller about cults and alien abductions.